Synthesis of Bis ( indolyl ) methanes by using

A novel synthetic methodology for the synthesis of Bis(indolyl)methanes by using catalytic amount of ferric triflate was described Introduction Bis(indolyl)methanes consists two substituted indole units in the molecule. Bis indole derivatives are reported to exhibit a wide spectrum of pharmacological activities such as cytotoxic, antitumor antimicrobial [1] and antiactivities. [2] For the past few years, much attention has been paid for the synthesis of Bis indolyl metabolites in view of their novel structural feature and broad spectrum of biological activities. [3] Lately, Bis(indole) alkaloids, comprise of two indole moieties connected to each other via heterocyclic units are isolated from plants and sponge Scheme 1. Synthesis of bis-indolylmethanes using Ferric triflate. ---------------------------------------------------------------Corresponding Author* E-mail: [email protected] 5, 334-338 ferric triflate as a catalyst